Clinical characteristics of patients with cerebellar ataxia associated with anti-GAD antibodies.

نویسندگان

  • Tiago Silva Aguiar
  • Andrea Fragoso
  • Carolina Rouanet de Albuquerque
  • Patrícia de Fátima Teixeira
  • Marcus Vinícius Leitão de Souza
  • Lenita Zajdenverg
  • Soniza Vieira Alves-Leon
  • Melanie Rodacki
  • Marco Antônio Sales Dantas de Lima
چکیده

Methods This retrospective and descriptive study evaluated the clinical characteristics and outcomes of patients with CA-GAD-ab. Result Three patients with cerebellar ataxia, high GAD-ab titers and autoimmune endocrine disease were identified. Patients 1 and 2 had classic stiff person syndrome and insidious-onset cerebellar ataxia, while Patient 3 had pure cerebellar ataxia with subacute onset. Patients received intravenous immunoglobulin therapy with no response in Patients 1 and 3 and partial recovery in Patient 2. Conclusion CA-GAD-ab is rare and its clinical presentation may hamper diagnosis. Clinicians should be able to recognize this potentially treatable autoimmune cerebellar ataxia.

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عنوان ژورنال:
  • Arquivos de neuro-psiquiatria

دوره 75 3  شماره 

صفحات  -

تاریخ انتشار 2017